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"Heavy marijuana use can boost blood levels of a particular protein, perhaps raising a person’s risk of a heart attack or stroke, U.S. government researchers said on Tuesday. …The marijuana users in the study averaged smoking 78 to 350 marijuana cigarettes per week."

http://www.reuters.com/article/healthNews/idUSN1231013620080513

 That's 3.125 joints per hour, assuming they only sleep 8 hours a day (which is not likely the case for someone clipping along at the rate of 3.125 jph). It's a self-report, and I'm guessing they had a funny guy in their study, because I'm not even sure that would be remotely possible. I also love how they consistently refuse to isolate variables in studies like this. If I were smoking 80 joints a week, I'd certainly be at higher risk for heart disease, but I'd also be consuming an indeterminate amount of Ho-Hos, Cinnamon Toast Crunch, and Doritos. Not that I really care too much about the science of a substance I don't smoke, but it really irks me when they call studies like this scientific.

If you eat 200 lbs of nutra sweet a day you might get cancer.

Here is one of the test subjects, everything seems legit to me: